Adjuvant Therapies and Markers of Post-Surgical Minimal by P. Denoix, G. Mathé (auth.), Professor Gianni Bonadonna,

By P. Denoix, G. Mathé (auth.), Professor Gianni Bonadonna, Professor Georges Mathé, Professor Sydney E. Salmon (eds.)

P. Denoix and G. Mathe nearly 70% of melanoma sufferers relapse after surgical procedure prior to the fifth yr and, generally, for instance in breast carcinoma, they relapse nonetheless later as much as the 20 th 12 months. For a few substantial time, the method of melanoma therapy has been restricted to the sophistication of surgery-radiotherapy mixtures that maximally lowered the prevalence of neighborhood and nearby relapses in websites that have been inside their succeed in. this present day, the perform of medical oncology is unthinkable with no the energetic participation of the scientific oncologist. he's the "third guy" of the scientific oncology crew, and he has lately targeted consciousness at the proven fact that so much relapses come up from far away metastases a result of proliferation of cells seeded there after having left the first tumor website on the time of operation and, consequently, are inaccessible to any shape oflocal and/or neighborhood therapy. in this facts, scientific oncologists have proposed the appliance of scientific remedies for disseminated minimum residual sickness (MRD). they've got on hand capacity: chemother­ apy and immunotherapy. scientific oncologists in most cases should be divided into 3 teams: chemotherapists, immunotherapists, and chemoimmunotherapists. The natural chemotherapists, who had already cured a few malignant neoplasias reminiscent of Hodgkin's affliction, acute lymphoid leukemia, placental choriocarcinoma, and Wilms' tumor, proposal they could have the technique of attacking the residual affliction of universal cancers.

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Weintraub, B. , Vaitukaitis, J. , Sussman, H. , Hershman, J. , Muggia, F. : Placental proteins and their subunits as tumor markers. Ann. Intern. Med. 82, 71-83 (1975) 19. , Nicholson, W. , Orth, D. : The nature ofimmunoreactive LPHs in human plasma and tissue extracts. J. Clin. Invest. (1978) (in press) 20. Yalow, R. , Berson,~. : Size heterogeneity of immunoreactive human ACTH in plasma and in extracts of pituitary glands and ACTH-producing thymoma. Biochem. Biophys. Res. Commun. 44, 439-445 (1971) Prognostic Value of Postoperative Blood Levels of Carcinoembryonic Antigen (CEA) in Breast Cancer R.

______________- u Years 2 Fig. 7. 08). CEA and Metastatic Disease The prognostic significance of CEA values in 260 patients with metastatic disease is shown in Fig. 7. Survival has been measured from the date of CEA estimation. The patients have been followed a mean period of 256 days. There is a highly significant difference in survival. 4 years, but the patients whose CEA is normal have not yet reached their median survival, which probably will be greater than 2 years. We have"analyzed the two groups, CEA positive and negative, for extent and sites of disease and found no difference in tumour burden.

Malkin, J. A. Kellen, and A. Malkin Introduction Carcinoembryonic antigen (CEA) was originally described by GOLD in 1965. Initial studies suggested that this assay might provide a method for identifying patients with colon cancer. However, the early promise of specificity for colon cancer has not been confirmed by the antigen and antibody preparations currently available and, in fact, abnormally elevated levels ofCEA have been found in a wide variety of tumours, other non-malignant diseases, and after blood transfusion.

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